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 +6012-4889321 / +6012 6080661    info@fats.my

ALLEGRI MASSIMO



ALLEGRI MASSIMO

PERSONAL INFORMATION

Name: ALLEGRI MASSIMO
Address: STRADA REPUBBLICA 35, 43121 PARMA, ITALY
Telephone: +39 3493540151
E-mail: allegri@italianpaingroup.com, allegrimassimo@yahoo.it
Nationality: Italian

WORK EXPERIENCE

Clinical/Research Working Responsibilities Dates (from – to)
2018- now Head Pain Therapy Service Policlinico Monza, Monza – Italy
2018- now Responsible Pain Therapy Center Columbus Clinic Center, Milan – Italy 2018- now Scientific Head of M3Salus Society (Society that provides multidisciplinary pain therapy services to private Hospitals)
2018- now Founder of Italian Pain Group
2014-2017 Responsible for Clinical Activity of Pain Therapy at University of Parma Hospital (8,500 visits/year, more than 4,000 procedures/year) on behalf of the Director of Anesthesia, Intensive Care and Pain Therapy Service, Parma University Hospital 2014-2017 Responsible for Unit of Research in Chronic Pain at University of Parma; including management and oversight of a laboratory dedicated to research in genomics and pain, and including the following personnel: 2 physicians, 2 biologists, 2 nurses, 1 psychologist and 1 laboratory dedicated to genomics and pain
2003-2014 Responsible for the Acute Pain Service for Urology and General Surgery IRCCS (National Research Hospital) University of Pavia Hospital
2010-2014 Responsible for Research in Acute and Chronic Pain for University of Pavia 2003-2014 Responsible for Acute and Chronic Pain for IRCCS University of Pavia Hospital

Academic Appointments Dates (from – to)
2017- Passed national exam, approved as Full Professor in Anesthesia, Intensive Care and Pain Medicine, University of Parma
2015- Member of the Research Institute Center BioGeNap, research institute in collaboration with University of Parma and Italian Center of National Research (CNR) 2015- Assistant Professor, Anesthesia, Intensive Care and Pain Medicine, University of Parma
2013- Passed national exam, approved as Associate Professor, Anesthesia, Intensive Care and Pain Medicine, University of Pavia
2010-2015 – Assistant Professor, Anesthesia, Intensive Care and Pain Medicine, University of Pavia
2015-2016 Responsible for Internship in Anesthesia and Emergency Care in Dental

Academic Teaching Dates (from – to)
University, University of Parma
2013-2017 Teacher and Responsible for 2nd Level Master Degree in Pain Therapy, University of Parma
2013-2017 Teacher and Responsible for 2nd Level Master Degree in Palliative Care, University of Parma
2013-2014 Teacher of Nursing in Critical Care, Nursing University, University of Pavia 2012-2014 Teacher of Emergency and Critical Care in the following courses: Dental Care; Biomedical Technician; Technician in Radiology; Dietology; Techinician in Orthopedics; Technician in Neurophysiopathology; Technician in Cardiovascular Surgery

Other Working Experience Dates (from – to)
2015- Referee of Medical Research Council (Regno Unito) del MRC Research Grants Board per valutazione di progetti di ricerca
2014-2018 Assistant Professor, Department Surgical Sciences, Section of Anesthesiology Intensive Care and Pain Therapy, University of Parma (Italy)
2014-2018 Anesthesia Intensive Care and Pain Therapy Department, Azienda Ospedaliera University of Parma Hospital
2010-2014 Assistant Professor, Department of Resuscitation and Organ Transplantation Surgery Sciences, Section of Anesthesiology and Resuscitation, Medicine University, University of Pavia (Italy)
2008 Research conducted at “Pain Clinic Inselspital” Bern (Switzerland) and at “Pain Clinic Massachussets General Hospital – Harvard Medical School” Boston (USA)
2003-2014 Worked in the Anaesthesia, Intensive Care and Pain Unit, Policlinico S. Matteo I.R.C.C.S. Foundation of Pavia (Italy)
2003- Research conducted at “Pain Clinic Hospital del Mar” Barcelona (Spain) and at “Pain Clinic Hospital Maria Midddalares” Sint Niklaas (Belgium)
2003 Participation in “Teorical- Practice Master in diagnosis and therapy of pain” Centro Studi Fondazione Maugeri, Pavia (Italy)
1999-2003 Clinical research in “Pain Therapy Unit” Fondazione IRCCS Salvatore Maugeri, Pavia (Italy)

Name and address of employer
Fondazione Policlinico Monza, M3Salus

Type of business or sector
Medicine

Occupation held
Medical Doctor

Main activities and responsibilities
2015-now Faculty member of International Group F1000 (Section Pain Management: Chronic Clinical Section in the Anesthesiology & Pain Management Faculty). http://f1000.com/prime/thefaculty/member/499999771097554741
2012-2014 Responsible for Research of Federdolore -SICD Italian Society for Acute and Chronic Pain
2013- Member of International Association for the Study of Pain (IASP)
2012-2013 Member of the Scientific Board of BEACON Project of Federal Drug Administration (FDA) regarding non-steroidal anti-inflammatory drugs (NSAIDs) and pain
2012- Member of Scientific Board of Fondazione ISAL
2008- President of SIMPAR (Study In Multidisciplinary Pain Research) research group (including responsibility for scientific direction)
2008-2014 Responsible for Research in Acute and Chronic Pain Fondazione IRCCS Policlinico San Matteo, Pavia
2007-2010 Scientific Member of Fondazione IRCCS Policlinico San Matteo in the “Development of Pavese Area in Biomedical Research” Project
2006-2015 Member of European Society of Regional Anesthesia
2006-2012 Secretary of European Society of Regional Anesthesia – Italian Chapter
2006-2014 Professor of Anesthesiology and Pain Therapy in Orthopedic Postgraduate School, University of Pavia
2006-2014 Co-Founder and Chief of “Center for Pain in Interstitial Cistitis” in Fondazione IRCCS Policlinico San Matteo
2006 Professor at “Theoretical-Practical Pain Therapy Master”– Fondazione IRCCS S. Maugeri – Pavia – Italy
2005-2014 Assistant Professor in Pain Therapy, Anaesthesiology and Urgent Medicine and Dentistry, University of Pavia
2003- Research (scientific and clinical) interest is with respect to pain therapy- particularly, genetics and pain, low back pain, cancer pain, chronic pelvic pain and mini- interventional pain management.

Education, training
2015 Fellowship in Interventional Pain Practice – FIPP
2003 Postgraduate Degree in Anaesthesiology, Intensive Care and Pain Therapy, University of Pavia (Italy) (50/50 cum laude)
1999-2003: Postgraduate School in Anaesthesia, Intensive Care and Pain Therapy, University of Pavia (Italy)
1999: Degree in Medicine, University of Pavia (110/110 cum laude) with the work “Efficacia della neurostimolazione spinale in pazienti affetti da dolore cronico intrattabile” presented and published at the 9th World Congress on Pain. Progress in Pain Research and Management. I.A.S.P. 1999. Vol.16.pp.993-998.

SCIENTIFIC EXPERIENCE

Research collaboration with international groups
2017- Member and local Principal Investigator of Research Consortium BackUp (Project funded by H2020 grant of European Commission) with Universidad de Valencia, Karolinska Institute (Sweden), University of Sheffield (UK), Centralny Institut Ochrony Pracy (Poland), University of Keele (UK)
2013-2017- Principal Investigator of PainOmics Consortium (Project funded by FP7 grant of European Commission) with Ziekenhuis Oost-Limburg Autonome Verzorgingsinstelling Hospital (Belgio), St. Catherine Hospital (Croazia), King’s College University (UK), Helmholtz Zentrum Muenchen University (Germania), Wake Forest University Baptish Health and Novant Medical Center (USA)
2007- President of Study In Multidisciplinary PAin Research (SIMPAR) in collaboration with McGill University (Canada), Stanford University (USA), MD Anderson Cancer Institute-University of Texas (USA), Valencia School of Medicine-Valencia General University Hospital (Spain), Aarhus University Hospital (Denmark), Karolinska Institutet (Sweden), St Luc Hospital UCL Medical School (Belgium)
2016- Clinical trial about genomics and radiofrequency in collaboration with Guy’s and St. Thomas’ NHS Foundation Trust Hospital, London (UK). Results are being currently under evaluations
2015- Clinical trial about biomarkers to predict sepsis after abdominal surgery in collaboration with Norwegian University of Science and Technology Trondheim (Norway). Results are being currently under evaluations

Clinical Trials and Research Activity
PI of more than 20 multicenter and single center clinical trials, enrolling more than 3,000 patients
2014- Scientific Project Leader, three International multicenter clinical trials: “Genetics and Low Back Pain” in the PainOmics Project (Project funded by European Community
– FP7 Project, 6€ Milion of euros)
2013-2016 Scientific Project Leader, multicenter clinical trial: “Prolonged Administration of Intra-wound Local Anesthetics for Acute Postoperative Pain in Abdominal Surgery” (Project funded by Italian Health Ministry – Giovani Ricercatori)
2013-2016 Scientific Project Leader, multicenter clinical trial: “Prolonged Administration Of Intra-Wound Local Anesthetics for Acute Postoperative Pain in Breast Surgery and Abdominal Surgery”
2012- Scientific Project Leader, multicenter clinical research study: “Opioids in Chronic Pain – Italian Registry”
2011-2013 Scientific Project Leader, multicenter clinical trial: “Pharmacogenetic and Postoperative Pain”
2010-2012 Scientific Project Leader, single center clinical trial: “Randomized Clinical Trial About Treatment of Postoperative Pain After Inguinal Repair and Prevention of Chronic Persistent Pain”
2008-2013 Scientific Project Leader, research on “Pharmacogenomics of Opioids in Acute and Chronic Pain”
2007-2010 Scientific Project Leader, research on the economic evaluation of Acute Chronic Pain Service
2006-2012 Scientific Project Leader, research on evaluation of pharmacokinetics of levobupivacaine and ropivacaine in postoperative period
2005-2012 Local Principal Investigator on numerous multicenter clinical trials
2005- Local Scientific Director of the multicentric randomized study on spinal cord stimulation and refractory angina.
2002- Speaker at numerous national and international meetings
2008- Scientific Board Member for 14 International meetings, including an International Association for the Study of Pain (IASP) workshop, World Institute of Pain (WIP), European Pain Federation of IASP Chapter (EFIC) and Study In Multidisciplinary PAin Research (SIMPAR)
2002 Participation in European Workshop for Implantable Infusion Pumps at European Surgical Institute, Hamburg (Germany)
1997 Winner of ERASMUS Award at Complutense University of Madrid

Grants won as Principal Investigator
Winner as Principal Investigators of 3 grants for a whole of 6.400.000 euros
1. 2013 Grant funded by European Community FP7 Project “PainOMICS” (Genomics and low back pain) (Proposal No: 602736-2) with 9 European Centers, 1 USA Center and 1 Australian Center – Grant for 5 years for 6 millions Euro
2. 2012-2016 Grant “Ricerca Finalizzata Ministero della Salute Bando Giovani Ricercatori – Ricerca con l’estero” (Italian Ministry of Health): “New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids” (Project Code:GR-2010-2318370) with Methodist Research Institute – Houston USA. Grant for 3 years for 350,000 Euro
3. 2010-2012 Grant “Bank del Monte di Pavia” about “pharmacogenetics and pain” Grant for 2 years for 45,000 Euro

Grants won as Local Principal Investigator
Winner as Principal Investigators of 2 grants for a whole of 6.020.000 euros
1. 2017- Grant funded by European Community H2020 Project “BackUp” (genomics and personalized medicine to neck and low back pain) coordinated by Instituto de Biomecánica Universitat Politècnica de València Spain – Grant for 3 years for 5.7 million Euro (coordinated Parma University submission and awarded 370,000 Euro for my lab)
2. 2017- Grant funded by Fondazione Cariplo Bank about “The study of chronic pain and responses to opioid treatment to unveil pathophysiological mechanisms of frailty. Experimental and clinical study”. Grant for 3 years for 320,000 Euro (coordinated Parma University submission and awarded 147,000 Euro for my lab)

Research interests
All research activities have been conducted utilizing a translational approach to discover new personalized medicine approaches in the following areas:
-Low back pain
-Neuropathic pain
-Spinal cord stimulation and pain
-Chronic postoperative pain
-Genomics and pharmacogenetics in acute/chronic pain: I have enrolled more than 2,000 patients in genomics clinical trials
-New clinical and laboratory biomarkers of pain and for pain diagnosis

Editorial and Scientific Activity
2017- Section Editor “Clinical Science and Pain Management” of Pain Practice Journal
2016- Associate Editor Pain Research and Management Journal
2013- Editor in Chief Fighting Pain Journal
2012- Section Editor (Pain and Anesthesia) for Minerva Anestesiologica
2006- Peer Reviewer for “European Journal of Anaesthesiology”, “Clinical Journal of Pain”, “Journal of Anesthesia and Clinical Research”

Participated in the translation of two handbooks of pain therapy:
1. 2002 – “Bonica’s Trattamento del Dolore”
2. 2002 – “Manual of Pain Management” – Second edition – Warfield CA, Fausett HJ, Lippincott Williams & Wilkins

Co-author of the following books:
a. L’anestesia dell’arto superiore 100 anni dopo (1911-2011) – Verducci Editori 2011
b. “Pavia Senza Dolore – Un legame tra ospedale e territorio. Guida all’offerta sanitaria per i medici di medicina Generale” eds Ordine dei Medici Pavia 2008
c. “I blocchi anestetici neurassiali” Guida Multimediale di Anestesia Locoregionale – “Mattioli 1885” Eds. published in 2008
d. “Il dolore – caratteristiche e indicazioni al trattamento”. FIMMG
e. “I blocchi anestetici dell’arto inferiore” Guida Multimediale di Anestesia Locoregionale – “Mattioli 1885” Eds. published in 2007
f. Chapter on “disordini elettrolitici e equilibrio acido base” – Trattato di Chirurgia Generale R. Dionigi Masson eds published in 2007
g. “I blocchi anestetici dell’arto superiore” Guida Multimediale di Anestesia Locoregionale – “Mattioli 1885” Eds. published in 2006

Author of 99 papers in peer review journals
H index 16 (web of science/Scopus), Impact factor 240

1. De Gregori M, Belfer I, De Giorgio R, Marchesini M, Muscoli C, Rondanelli M, Martini D, Mena P, Arranz LI, Lorente-Cebrián S, Perna S, Villarini A, Salamone M, Allegri M, Schatman ME. Second edition of SIMPAR’s “Feed Your Destiny” workshop: the role of lifestyle in improving pain management. J Pain Res. 2018 Aug 27;11:1627-1636
2. Amodeo G, Bugada D, Franchi S, Moschetti G, Grimaldi S, Panerai A, Allegri M, Sacerdote P. Immune function after major surgical interventions: the effect of postoperative pain treatment. J Pain Res. 2018 Jul 10;11:1297-1305.
3. Trbojević-Akmačić I, Vučković F, Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesini M, Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G. Plasma N-glycome composition associates with chronic low back pain. Biochim Biophys Acta. 2018 Jul 5;1862(10):2124-2133.
4. Cavaliere F, Allegri M, Apan A, Calderini E, Carassiti M, Coluzzi F, DI Marco P, Langeron O, Rossi M, Spieth P. A year in review in Minerva Anestesiologica 2017. Minerva Anestesiol. 2018 Feb;84(2):269-282.
5. Bignami E, Castella A, Allegri M. Postoperative Pain After Cardiac Surgery: An Open Issue. J Cardiothorac Vasc Anesth. 2018 Feb;32(1):e24-e25.
6. Bignami E, Castella A, Pota V, Saglietti F, Scognamiglio A, Trumello C, Pace MC, Allegri M. Perioperative pain management in cardiac surgery: a systematic review. Minerva Anestesiol. 2018 Apr;84(4):488-503.
7. Allegri M, Bugada D, De Gregori M, Avanzini MA, De Silvestri A, Petroni A, Sala A, Filisetti C, Icaro Cornaglia A, Cobianchi L. Continuous wound infusion with chloroprocaine in a pig model of surgical lesion: drug absorption and effects on inflammatory response. J Pain Res. 2017 Oct 31;10:2515-2524.
8. Bugada D, Allegri M, Gemma M, Ambrosoli AL, Gazzerro G, Chiumiento F, Dongu D, Nobili F, Fanelli A, Ferrua P, Berruto M, Cappelleri G. Effects of anaesthesia and analgesia on long-term outcome after total knee replacement: A prospective, observational, multicentre study. Eur J Anaesthesiol. 2017 Oct;34(10):665-672.
9. Cortesi PA, D’Angiolella LS, Vellucci R, Allegri M, Casale G, Favaretti C, Kheiraoui F, Cesana G, Mantovani LG. Cost-effectiveness analysis of oral fentanyl formulations for breakthrough cancer pain treatment. PLoS One. 2017 Jun 27;12(6):e0179523.
10. Fanelli G, De Carolis G, Leonardi C, Longobardi A, Sarli E, Allegri M, Schatman ME. Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients. J Pain Res. 2017 May 22;10:1217-1224.
11. Allegri M, Ornaghi M, Ferland CE, Bugada D, Meghani Y, Calcinati S, De Gregori M, Lovisari F, Radhakrishnan K, Cusato M, Scalia Catenacci S, Somaini M, Fanelli G, Ingelmo P. eritoneal Nebulization of Ropivacaine during Laparoscopic Cholecystectomy: Dose Finding and Pharmacokinetic Study. Pain Res Manag. 2017;2017:4260702
12. Dagostino C, De Gregori M, Gieger C, Manz J, Gudelj I, Lauc G, Divizia L, Wang W, Sim M, Pemberton IK, MacDougall J, Williams F, Van Zundert J, Primorac D, Aulchenko Y, Kapural L, Allegri M; PainOmics Group.. Validation of standard operating procedures in a multicenter retrospective study to identify –omics biomarkers for chronic low back pain. PLoS One. 2017 May 1;12(5):e0176372.
13. Baciarello M, Migliavacca G, Marchesini M, Valente A, Allegri M, Fanelli G. Transversus Abdominis Plane Block for the Diagnosis and Treatment of Chronic Abdominal Wall Pain Following Surgery: A Case Series. Pain Pract. 2017 Mar 14. [Epub ahead of print]
14. Bugada D, Allegri M, Grossi P, Manassero A, Pinciroli RL, Zadra N, Fanelli G, Zarcone A, Cataldo R, Danelli G, Borghi B. Regional anesthesia: the best is yet to come. Minerva Anestesiol. [Jul;83(7):774-775.
15. Lippi G, Dagostino C, Buonocore R, Aloe R, Bonaguri C, Fanelli G, Allegri M. The serum concentrations of leptin and MCP-1 independently predict low back pain duration. Clin Chem Lab Med. 2017 Aug 28;55(9):1368-1374.
16. Cavaliere F, Rossi M, Allegri M, Apan A, Calderini E, Carassiti M, Coluzzi F, DI Marco P, Langeron O, Piastra M. A year in review in Minerva Anestesiologica 2016. Minerva Anestesiol. 2017 Feb;83(2):225-236.
17. Compagnone C, Schatman ME, Rauck RL, Van Zundert J, Kraus M, Primorac D, Williams F, Allegri M, Saccani Jordi G, Fanelli G; Pain-Omics Group. Past, Present, and Future of Informed Consent in Pain and Genomics Research: Challenges Facing Global Medical Community. Pain Pract. 2017 Jan;17(1):8-15
18. Allegri M, Fanelli G. Opioids and chronic pain. Data from the “other side of the pond”. Minerva Anestesiol. 2017 Jan;83(1):6-8
19. De Gregori M, Muscoli C, Schatman ME, Stallone T, Intelligente F, Rondanelli M, Franceschi F, Arranz LI, Lorente-Cebrián S, Salamone M, Ilari S, Belfer I, Allegri M. Combining pain therapy with lifestyle: the role of personalized nutrition and nutritional supplements according to the SIMPAR Feed Your Destiny approach. J Pain Res. 2016 Dec 8;9:1179-1189.
20. Baron R, Allegri M, Correa-Illanes G, Hans G, Serpell M, Mick G, Mayoral V. The 5% Lidocaine-Medicated Plaster: Its Inclusion in International Treatment Guidelines for Treating Localized Neuropathic Pain, and Clinical Evidence Supporting its Use. Pain Ther. 2016 Dec;5(2):149-169
21. Allegri M, De Gregori M, Minella CE, Klersy C, Wang W, Sim M, Gieger C, Manz J, Pemberton IK, MacDougall J, Williams FM, Van Zundert J, Buyse K, Lauc G, Gudelj I, Primorac D, Skelin A, Aulchenko YS, Karssen LC, Kapural L, Rauck R, Fanelli G; PainOMICS Group. ‘Omics’ biomarkers associated with chronic low back pain: protocol of a retrospective longitudinal study. BMJ Open. 2016 Oct 19;6(10):e012070.
22. Allegri M, Montella S, Salici F, Valente A, Marchesini M, Compagnone C, Baciarello M, Manferdini ME, Fanelli G. Mechanisms of low back pain: a guide for diagnosis and therapy. Version 2. F1000Res. 2016 Jun 28 [revised 2016 Jan 1];5.
23. Bugada D, Bellini V, Fanelli A, Marchesini M, Compagnone C, Baciarello M, Allegri M, Fanelli G. Future Perspectives of ERAS: A Narrative Review on the New Applications of an Established Approach. Surg Res Pract. 2016;2016:3561249.
24. Gudelj I, Baciarello M, Ugrina I, De Gregori M, Napolioni V, Ingelmo PM, Bugada D, De Gregori S, Đerek L, Pučić-Baković M, Novokmet M, Gornik O, Saccani Jotti G, Meschi T, Lauc G, Allegri M. Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery. Sci Rep. 2016 Aug 9;6:31234.
25. De Gregori M, Scotti V, De Silvestri A, Curti M, Fanelli G, Allegri M, Schatman ME. Does a research group increase impact on the scientific community or general public discussion? Alternative metric-based evaluation. J Pain Res. 2016 Jun 11;9:391-5

26. Zorzetto L, Brambilla P, Marcello E, Bloise N, De Gregori M, Cobianchi L, Peloso A, Allegri M, Visai L, Petrini P. From micro- to nanostructured implantable device for local anesthetic delivery. Int J Nanomedicine. 2016 Jun 8;11:2695-709
27. Allegri M, Bugada D, Grossi P, Manassero A, Pinciroli RL, Zadra N, Fanelli G, Zarcone A, Cataldo R, Danelli G, Borghi B; Group on Behalf of RICALOR. Italian Registry of Complications associated with Regional Anesthesia (RICALOR). An incidence analysis from a prospective clinical survey. Minerva Anestesiol. 2016 Apr;82(4):392-402.
28. Bugada D, Lavand’homme P, Ambrosoli AL, Cappelleri G, Saccani Jotti GM, Meschi T, Fanelli G, Allegri M. Effect of Preoperative Inflammatory Status and Comorbidities on Pain Resolution and Persistent Postsurgical Pain after Inguinal Hernia Repair. Mediators Inflamm. 2016;2016:5830347.
29. Freidin MB, Keser T, Gudelj I, Štambuk J, VuKenoviK D, Allegri M, PaviK T, Šimurina M, Fabiane SM, Lauc G, Williams FM. The Association Between Low Back Pain and Composition of IgG Glycome. Sci Rep. 2016 May 27;6:26815.
30. Freidin MB, Lauc G, Allegri M, Primorac D, Williams FM. Using omics in chronic pain conditions to delineate mechanisms and provide new therapeutic strategies. Pain Manag. 2016;6(3):211-5.
31. De Gregori M, Diatchenko L, Ingelmo PM, Napolioni V, Klepstad P, Belfer I,
Molinaro V, Garbin G, Ranzani GN, Alberio G, Normanno M, Lovisari F, Somaini M, Govoni S, Mura E, Bugada D, Niebel T, Zorzetto M, De Gregori S, Molinaro M, Fanelli G, Allegri M. Human Genetic Variability Contributes to Postoperative Morphine Consumption. J Pain. 2016 May;17(5):628-36.
32. Cavaliere F, Allegri M, Calderini E, Carassiti M, Coluzzi F, Di Marco P, Piastra M, Rossi M. A year in review in Minerva Anestesiologica 2015. Minerva Anestesiol. 2016 Feb;82(2):243-5
33. Fanelli G, Tölle TR, De Andrés J, Häuser W, Allegri M, Montella S, Kress HG. Opioids for chronic non-cancer pain: A critical view from the other side of the pond. Minerva Anestesiol. 2016 Jan;82(1):97-102.
34. Allegri M, Baron R, Hans G, Correa-Illanes G, Mayoral Rojals V, Mick G, Serpell M. A pharmacological treatment algorithm for localized neuropathic pain. Curr Med Res Opin. 2016;32(2):377-84
35. Bugada D, Lavand’homme P, Ambrosoli AL, Klersy C, Braschi A, Fanelli G, Saccani Jotti GM, Allegri M; SIMPAR group. Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study. J Clin Anesth. 2015 Dec;27(8):658-64.
36. Maremmani I, Gerra G, Ripamonti IC, Mugelli A, Allegri M, Viganò R, Romualdi P, Pinto C, Raffaeli W, Coluzzi F, Gatti RC, Mammucari M, Fanelli G. The prevention of analgesic opioids abuse: expert opinion. Eur Rev Med Pharmacol Sci. 2015 Nov;19(21):4203-6.
37. Bugada D, De Gregori M, Compagnone C, Muscoli C, Raimondi F, Bettinelli S,Avanzini MA, Cobianchi L, Peloso A, Baciarello M, Dagostino C, Giancotti LA, Ilari S, Lauro F, Grimaldi S, Tasciotti E, Fini M, Saccani Jotti GM, Meschi T, Fanelli G, Allegri M. Continuous wound infusion of local anesthetic and steroid after major abdominal surgery: study protocol for a randomized controlled trial. Trials. 2015 Aug 14;16(1):357.
38. Perotti L, Cusato M, Ingelmo P, Niebel TL, Somaini M, Riva F, Tinelli C, De Andrés J, Fanelli G, Braschi A, Regazzi M, Allegri M. A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial. Anesth Analg. 2015 Aug;121(2):348-56.
39. De Gregori M, Diatchenko L, Belfer I, Allegri M. OPRM1 receptor as new biomarker to help the prediction of post mastectomy pain and recurrence in breast cancer. Minerva Anestesiol. 2015 Aug;81(8):894-900.
40. Scalia Catenacci S, Lovisari F, Peng S, Allegri M, Somaini M, Ghislanzoni L, Greco M, Rossini V, D’Andrea L, Buda A, Signorelli M, Pellegrino A, Sportiello D, Bugada D, Ingelmo PM. Postoperative Analgesia after Laparoscopic Ovarian Cyst Resection: Double-blind Multicenter Randomized Control Trial Comparing Intraperitoneal Nebulization and Peritoneal Instillation of Ropivacaine. J Minim Invasive Gynecol. 2015 Jul-Aug;22(5):759-66.
41. Chiumello D, Allegri M, Cavaliere F, De Cosmo G, Iohom G, Langeron O, Apan A, Spieth P, Capogna G. A year in review in Minerva Anestesiologica 2014. Minerva Anestesiol. 2015 Feb;81(2):238-49.
42. Casale R, Romanenko Y, Allegri M. 5% lidocaine medicated plaster double effect in a case of orofacial localized neuropathic pain. J Pain Res. 2014 Nov 24;7:639-43.

43. Taraballi F, Minardi S, Corradetti B, Yazdi IK, Balliano MA, Van Eps JL, Allegri M, Tasciotti E. Potential avoidance of adverse analgesic effects using a biologically “smart” hydrogel capable of controlled bupivacaine release. J Pharm Sci. 2014 Nov;103(11):3724-32.
44. Casale R, Di Matteo M, Minella CE, Fanelli G, Allegri M. Reduction of painful area as new possible therapeutic target in post-herpetic neuropathic pain treated with 5% lidocaine medicated plaster: a case series. J Pain Res. 2014 Jun 23;7:353-7.
45. Bugada D, Allegri M, Lavand’homme P, De Kock M, Fanelli G. Inflammation-based scores: a new method for patient-targeted strategies and improved perioperative outcome in cancer patients. Biomed Res Int. 2014;2014:142425.
46. Gigliuto C, De Gregori M, Malafoglia V, Raffaeli W, Compagnone C, Visai L, Petrini P, Avanzini MA, Muscoli C, Viganò J, Calabrese F, Dominioni T, Allegri M, Cobianchi L. Pain assessment in animal models: do we need further studies? J Pain Res. 2014 May 8;7:227-36.
47. Gardella B, Porru D, Allegri M, Bogliolo S, Iacobone AD, Minella C, Nappi RE, Ferrero S, Spinillo A. Pharmacokinetic considerations for therapies used to treat interstitial cystitis. Expert Opin Drug Metab Toxicol. 2014 May;10(5):673-84.
48. De Gregori S, Minella CE, De Gregori M, Tinelli C, Ranzani GN, Govoni S, Allegri M, Regazzi M. Clinical pharmacokinetics of morphine and its metabolites during morphine dose titration for chronic cancer pain. Ther Drug Monit. 2014 Jun;36(3):335-44.
49. Compagnone C, Tagliaferri F, Allegri M, Fanelli G. Ethical issues in pain and omics research. Some points to start the debate. Croat Med J. 2014 Feb;55(1):1-2.
50. Chiumello D, Allegri M, Cavaliere F, De Cosmo G, Iohom G, Langeron O, Apan A, Spieth P, Capogna G. A year in review in Minerva Anestesiologica 2013. Minerva Anestesiol. 2014 Feb;80(2):266-80
51. Bugada D, Guardia Nicola F, Carboni V, Allegri M. Transversus abdominis plane catheter infusions after major abdominal surgery in morbidly obese patients: reply to comments. Minerva Anestesiol. 2014 Jun;80(6):747.
52. Breivik H, Eisenberg E, O’Brien T; OPENMinds.(Allegri M) The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care. BMC Public Health. 2013 Dec 24;13:1229.
53. Fanelli A, Ghisi D, Allegri M. Is spinal anaesthesia a suitable technique for ultra-short outpatient procedures? Acta Biomed. 2013 Jun1;84(1):76-80.
54. Coluzzi F, Valensise H, Sacco M, Allegri M. Chronic pain management in pregnancy and lactation. Minerva Anestesiol. 2014 Feb;80(2):211-24.
55. Bugada D, Guardia Nicola F, Carboni V, Allegri M. TAP block for opioid-free postoperative analgesia in obese surgery. Minerva Anestesiol. 2013Dec;79(12):1447- 8.
56. De Gregori M, Garbin G, De Gregori S, Minella CE, Bugada D, Lisa A, Govoni S, Regazzi M, Allegri M, Ranzani GN. Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain. Eur J Clin Pharmacol. 2013 Sep;69(9):1651-8.
57. Mura E, Govoni S, Racchi M, Carossa V, Ranzani GN, Allegri M, van Schaik RH. Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside? J Pain Res. 2013 May 1;6:331-53
58. Chiumello D, Allegri M, Cavaliere F, De Cosmo G, Iohom G, Langeron O, Pietrini D, Rossi M. A year in review in Minerva Anestesiologica 2012. Minerva Anestesiol. 2013 Apr;79(4):454-70.
59. Porru D, Leva F, Parmigiani A, Barletta D, Choussos D, Gardella B, Daccò MD, Nappi RE, Allegri M, Tinelli C, Bianchi CM, Spinillo A, Rovereto B. Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. Int Urogynecol J. 2012 Sep;23(9):1193-9.
60. Allegri M, Clark MR, De Andrés J, Fanelli G. Pain treatment: A new approach to link bench to bedside – the SIMPAR meeting 2011. Eur J Pain. 2012 2012 Jul;16(6):779-81
61. De Gregori S, De Gregori M, Ranzani GN, Allegri M, Minella C, Regazzi M. Morphine metabolism, transport and brain disposition. Metabolic Brain Disease 2012 Mar;27(1):1-5.
62. Allegri M, Clark MR, De Andrés J, Jensen TS. Acute and chronic pain: where we are and where we have to go. Minerva Anestesiol. 2012 Feb;78(2):222-35
63. Allegri M, Grossi P. Management of postoperative pain: how accurate and successful is our acute pain management? Minerva Anestesiol. 2011 Jul 13. 2012 Jan;78(1):1-3
64. Sprintz M, Tasciotti E, Allegri M, Grattoni A, Driver LC, Ferrari M. Nanomedicine: ushering in a new era f pain management. European Journal of Pain Supplement 2011;5(2):317-322

65. De Gregori S, Niebel T, Minella CE, Allegri M, Regazzi M. How pharmacokinetics can help to choose the right opioids during PCA and opioid treatment. European Journal of Pain Supplement 2011;5(2):3477-484.
66. Allegri M. Analgesia – methods and protocols. Eur J Histochem. 2011 Mar 25;55(1):ejh.2011.br1
67. Eriksson BI, Dahl OE, Huo MH, Kurth AA, Hantel S, Hermansson K, Schnee JM, Friedman RJ; RE-NOVATE II Study Group (Allegri M). Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II*). A randomised, double-blind, non-inferiority trial. Thromb Haemost. 2011 Apr;105(4):721-9
68. Greco MT, Corli O, Montanari M, Deandrea S, Zagonel V, Apolone G; Writing Protocol Committee; Cancer Pain Outcome Research Study Group (CPOR SG) Investigators (Allegri M). Epidemiology and pattern of care of breakthrough cancer pain in a longitudinal sample of cancer patients: results from the Cancer Pain Outcome Research Study Group. Clin J Pain. 2011 Jan;27(1):9-18.
69. Lanza GA, Grimaldi R, Greco S, Ghio S, Sarullo F, Zuin G, De Luca A, Allegri M, Di Pede F, Castagno D, Turco A, Sapio M, Pinato G, Cioni B, Trevi G, Crea F. Spinal cord stimulation for the treatment of refractory angina pectoris: A multicenter randomized single-blind study (the SCS-ITA trial). Pain. 2011 Jan;152(1):45-52.
70. Bugada D, Allegri M, Zadra N, Braschi A, Borghi B, Grossi P, RICALOR Group Investigators (2011). Regional anesthesia and anticoagulant drugs: a survey of current italian practice. European Journal Of Pain Supplements 2011;5:335-344
71. Massimo Allegri, Thekla Niebel, Dario Bugada, Flaminia Coluzzi, Marco Baciarello, Marco Berti, Carmine Tinelli, Battista Borghi, Paolo Grossi, and RICALOR Group Investigators Regional analgesia in Italy: A survey of current practice. European Journal of Pain Supplement 2010 Nov;4(4):219-226
72. Pablo M. Ingelmo, Marta Somaini, Mario Bucciero, Massimo Allegri, Dario Bugada, Maria Cusato and Pierre Diemunsch. Nebulization of local anaesthetics in laparoscopic surgery: A new tool for postoperative analgesia. European Journal of Pain Supplement 2010 Nov;4(4):235-238.
73. Grossi P, Barbaglio C, Violini A, Allegri M, Niebel T. Regional anesthesia update. Minerva Anestesiologica, 2010;76: 629-636
74. Manuela De Gregori, Simona De Gregori, Guglielmina N. Ranzani, Massimo Allegri, Stefano Govoni and Mario Regazzi. Individualizing pain therapy with opioids: The rational approach based on pharmacogenetics and pharmacokinetics. European Journal of Pain Supplement 2010 Nov;4(4):245-250.
75. Michela Zacchino, Massimo Allegri, Mario Canepari, Cristina E. Minella, Silvia Bettinelli, Ferdinando Draghi and Fabrizio Calliada. Feasibility of pudendal nerve anesthetic block using fusion imaging technique in chronic pelvic pain. European Journal of Pain Supplement 2010 Nov;4(4):329-333
76. Allegri M, De Gregori M, Niebel T, Minella C, Tinelli C, Govoni S, Regazzi M, Braschi
A. Pharmacogenetics and postoperative pain: a new approach to improve acute pain management. Minerva Anestesiol. 2010 Nov;76(11):937-44.
77. Cusato M, Allegri M, Niebel T, Ingelmo P, Broglia M, Braschi A, Regazzi M. Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate. Eur J Clin Pharmacol. 2011 Apr;67(4):399-406
78. M. Allegri, Lombardi F, Scagnelli P, Corona M, Minella CE, Braschi A, Arienta C. Spontaneous cervical (C1-2) cerebrospinal fluid leakage repaired with TC-guided cervical epidural blood patch: a case report. J Pain Sympt Management. J Pain Symptom Manage. 2010 Sep;40(3):e9-e12
79. Allegri M, Bugada D, Grossi P. Central Neural Blockade and antiinflammatory drugs. Minerva Anestesiologica. 2010 76;10(1):46-49
80. Grossi P, Barbaglio C, Violini A, Allegri M, Thekla N. Regional anesthesia update. Minerva Anestesiol. 2010 2010 Aug;76(8):629-36
81. M. Allegri, Niebel T, Baldi C, Bettinelli S, Cusato M, Braschi A, Regazzi M. Plasma concentrations of levobupivacaine increases under continuous infusion after major surgery. Acta Anesthesiologica Scandinavica. 2010 May;54(5):654-5.
82. De Gregori M, Allegri M, De Gregori S, Garbin G, Tinelli C, Regazzi M, Govoni S, Ranzani GN. How and Why to Screen for CYP2D6 Interindividual Variability in Patients Under Pharmacological Treatments. Curr Drug Metab. 2010 Mar 1;11(3):276- 82.
83. C Bonezzi, E Pitino, M Allegri. Analysis of a population of patients who referred to a second level pain center. Clinical and demographic characteristics. European Journal of Pain Supplement 2009 Nov; 3(2):17-20
84. M Allegri, MG Delazzo, P Grossi, B Borghi. Efficacy of drugs in regional anesthesia: a

review. European Journal of Pain Supplement 2009 Nov; 3(2):41-48
85. C Bonezzi, M Allegri, L Demartini, M Buonocore. The pharmacological treatment of neuropathic pain. European Journal of Pain Supplement 2009 Nov; 3(2):85-88
86. M. Allegri. Postoperative pain in Italy: an update. Minerva Anestesiol. 2009 Nov;75(11):604-6.
87. Allegri M, Niebel T, Grossi P, Braschi A. Regional Anesthesia in breast surgery. Something new? Minerva Anestesiologica 2009;75(1):69-76
88. Allegri M, Silva M, Grossi P, Braschi A. Local anesthetc toxicity:what we have to know. Minerva Anestesiologica 2009;75(1):460-462
89. Apolone G, Corli O, Negri E, Mangano S, Montanari M, Greco MT; Cancer Pain Outcome Research Study Group (CPOR SG) Investigators (Allegri M), Apolone G, Bertetto O, Caraceni A, Corli O, De Conno F, Labianca R, Maltoni M, Nicora Maria F, Torri V, Zucco F. Effects of transdermal buprenorphine on patients-reported outcomes in cancer patients: results from the Cancer Pain Outcome Research (CPOR) Study Group. Clin J Pain. 2009 Oct;25(8):671-82.
90. Allegri M, Baldi C, Pitino E, Cusato M, Regazzi M, Braschi A.. An accidental intravenous infusion of ropivacaine without any adverse effects. J Clin Anesth. 2009 Jun;21(4):312-3
91. Apolone G, Corli O, Caraceni A, Negri E, Deandrea S, Montanari M, Greco MT; Cancer Pain Outcome Research Study Group (CPOR SG) Investigators. Pattern and quality of care of cancer pain management. Results from the Cancer Pain Outcome Research Study Group (Allegri M). Br J Cancer. 2009 May 19;100(10):1566-74.
92. M. Allegri, C. Tinelli, G. Sandrini and C. Bonezzi. 30 years of pain treatment in Italy: past, present and future. European Journal of Pain Supplement 2008 Oct; 2(1):1-4
93. Massimo Allegri, Paolo Grossi, Federica Ferrari and Battista Borghi. Regional anaesthesia and side effects: is it safe? European Journal of Pain Supplement 2008 Oct; 2(1):31-35
94. Delvecchio L, Bettinelli S, Klersy C, Allegri M, Cavalloro F, Braschi A. Comparing the efficacy and safety of continuous epidural analgesia in abdominal and urological surgery between two opioids with different kinetic properties: morphine and sufentanyl. Minerva Anestesiologica 2008 Mar;74(3):69-76
95. M Allegri. Vertebral Augmentation: toward a safe and pain-free methodic for back pain. Editorial. Minerva Anestesiologica 2008 Mar;74(3):53-54.
96. Baldi C, Bettinelli S, Grossi P, Fausto A, Sardanelli F, Cavalloro F, Allegri M, Braschi A: Ultrasound guidance for locoregional anesthesia: a review. Minerva Anestesiol; 2007 Nov;73(11):587-93.
97. P Grossi, M Allegri. Continuous peripheral nerve blocks: state of the art. Current Opinion in Anaesthesiology 2005;18(5):522-527..
98. Allegri M, Arachi G, Barbieri M, Paulin L, Bettaglio R, Bonetti G, Demartini L, Violini A, Braschi A, Bonezzi C. Prospective study of the success and efficacy of spinal cord stimulation. Minerva Anestesiol. 2004 Mar;70(3):117-24.
99. Negri E, Bettaglio R, Demartini L, Allegri M, Barbieri M, Miotti D, Paulin L, Buonocore M, Bonezzi C. Validation of the Italian version of the “Neuropathic Pain Scale” and its clinical applications. Minerva Anestesiol. 2002 Mar;68(3):95-104

Name and type of organisation providing education and training
University of Pavia

Principal subjects/occupational skills covered
Anaesthesia: epidural anaesthesia, regional anaesthesia, clinical pharmacology of local anesthethics.
Acute and chronic pain: acute pain service, chronic pelvic pain, chronic pain and spinal cord stimulation, clinical pharmacology of opioids, oncologic pain.
Genetics and genomics and pain

Title of qualification awarded
Assistant Professor in Anesthesia, Intensive Care and Pain Medicine

Level in national classification (if appropriate)
Full Professor in Anesthesia, Intensive Care and Pain Therapy (2017) Associate Professor in Anesthesia, Intensive Care and Pain Therapy (2013)

MOTHER TONGUE
ITALIAN

OTHER LANGUAGES

ENGLISH
• Reading skills EXCELLENT
• Writing skills VERY GOOD
• Verbal skills VERY GOOD

OTHER LANGUAGES

SPANISH
• Reading skills EXCELLENT
• Writing skills GOOD
• Verbal skills VERY GOOD


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